Duke Computer Science Colloquium

Antibiotics Discovery: From Genome Sequencing to Genome Mining to Peptidogenomics

Speaker:Hosein Mohimani
Date: Wednesday, March 22, 2017
Time: 12:00pm - 1:00pm
Location: D106 LSRC, Duke
Pizza will be served at 11:45.

Abstract

Genomics studies revealed numerous antibiotics-encoding genes across a wide range of bacterial and fungal species, including various species in the human microbiome. However, little is known about the hundreds of antibiotics produced by microorganisms in the gut, despite the fact that humans are chronically exposed to them. Deep exploration of this meta-antibiome critically depends on a transition from the current one-off process of antibiotics analysis to a high-throughput antibiotics sequencing. I will explain why antibiotics sequencing is relevant to the classical turnpike and beltway problems in computer science and will discuss recent advances in computational antibiotics discovery that span bioinformatics techniques ranging from genome/metagenome sequencing to genome mining to peptidogenomics.

Biography

Hosein Mohimani received his B.Sc. in Electrical Engineering and Mathematical Sciences from Sharif University of Technology, Iran (2008), and his Ph.D. in Electrical and Computer Engineering from University of California, San Diego (2013). At UC San Diego, Hosein worked on computational mass spectrometry methods for antibiotic discovery under the supervision of professor Pavel Pevzner. In 2013 Hosein Joined Illumina Inc., working on novel techniques for long read DNA sequencing. Since 2015, Hosein is a Project Scientist at UC San Diego, working on computational techniques for antibiotic discovery and microbiome analysis.

Hosted by:
Alex Hartemink